Identity and synonyms
Catalog label is recorded; analytical identity and equivalence are not established.
Nonpeptide agent · Amino acid or derivative
Detailed molecular class: Nonpeptide agent; see mechanism for subtype
Supplied sequence or chemical reference
PubChem CID: 9750
Molecular formula: C6H13N3O3
IUPAC: (2S)-2-amino-5-(carbamoylamino)pentanoic acid
Source: PC-CITRULLINE
Database chemical reference; does not certify supplier vial, salt, isomer or formulation.
Mechanism
Urea-cycle amino acid converted to arginine; free citrulline and citrulline malate are different materials.
Evidence and critical reading
Reported scientific and empirical uses
Reported muscle and performance · Replacement and nutritional context · Cardiovascular and vascular function
Sports supplementation for blood flow/performance; inclusion in an amino-acid vial does not demonstrate blend efficacy.
Human evidence
Small citrulline-malate trials found conflicting performance results: one in 41 men was favorable and another protocol showed no benefit. They are not evidence for injectable free citrulline or a multinutrient blend.
Preclinical evidence
Do not equate mechanism, cell culture or animal work with a clinical outcome. The specific level is detailed in the evidence assessment.
Critical reading and limitations
Small citrulline-malate trials found conflicting performance results: one in 41 men was favorable and another protocol showed no benefit. They are not evidence for injectable free citrulline or a multinutrient blend.
Small citrulline-malate trials found conflicting performance results: one in 41 men was favorable and another protocol showed no benefit. They are not evidence for injectable free citrulline or a multinutrient blend.
Source-specific regimens
Descriptive source observations, not individual recommendations.
Regulatory product labeling
Listed regimens preserve source/context. An empty layer means no regimen attributable to this identity was verified in this review; it does not prove universal absence of data.
Human-study exposure
NOT A RECOMMENDATION.Each amount is attributed to the source identified for that entry: regulatory product labeling, human research, or community and practice sources. These source categories have different evidentiary roles. They are not medical advice, not a protocol, not a recommended or safe dose, and not evidence that it works. Do not use them to start, change or stop any treatment. Talk to a qualified healthcare professional.
Reported by Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness
8 g of citrulline malate · Distinct formulation: citrulline malate; not free citrulline
- Frequency
- One exposure per condition
- Duration
- Acute, crossover trial
- Route
- Oral
- Context
- Citrulline malate, not 8 g of free citrulline or an injectable-blend regimen.
- Presentation
- A dosage-form presentation is not specified in the reviewed record.
- Interpretation
- Research exposure: not a prescription or starting regimen. It does not reconstruct protocol titration, exclusions or monitoring.
PMID20386132 · October 16, 2026
NOT A RECOMMENDATION.Each amount is attributed to the source identified for that entry: regulatory product labeling, human research, or community and practice sources. These source categories have different evidentiary roles. They are not medical advice, not a protocol, not a recommended or safe dose, and not evidence that it works. Do not use them to start, change or stop any treatment. Talk to a qualified healthcare professional.
Empirical handbook
Listed regimens preserve source/context. An empty layer means no regimen attributable to this identity was verified in this review; it does not prove universal absence of data.
Regulation and safety
Jurisdiction-specific regulatory context
This record does not verify FDA/EMA authorization of the commercial identity. Where a specific medicine/product exists, jurisdiction/indication are detailed in cited sources; they do not transfer to supplier material.
Adverse effects and unknowns
Distinguish pharmacologic vasodilation plausibility from a demonstrated clinical interaction. Supplier combinations are not validated.
Contraindications
A complete list must match the exact authorized product. For experimental materials without verified human labeling, a complete contraindication set is not established here. No list does not mean safety.
Interactions
Separate documented interaction, pharmacologic plausibility and unknown interaction. Absence of a blend trial does not establish compatibility.
Studies and trials
Selected studies
PMID20386132 · Randomized controlled trial
Men in an exercise protocol.
Oral citrulline malate, acute exposure.
Favorable repetition/muscle-soreness signal.
Another trial (PMID30097067) was negative; malate is not free citrulline or injection.
n = 41
Trials attributed in the package
No trials are attributed in this record.
Trial registration does not establish efficacy or validate commercial material.
Query candidates; attribution pending
Citrulline · 162 unfiltered query results, not authenticated trials
Query verification: October 16, 2026
Exact phrase intervention query; first three most recently updated records, not exhaustive. Aliases may be missed and heterogeneous products may appear. The total is the unfiltered registry query count, not authenticated trials. Source-integrity holds are excluded from ordinary listings.
View trial registry queryNCT07854223 · Effects of Pre-Run Nutritional Supplements During a Fixed-Pace 5 km Treadmill RunRegistry status: RecruitingLast update posted: October 2, 2026Query verification: October 16, 2026
NCT04979793 · Role of L-citrulline in Prevention of Pregnancy Associated HypertensionRegistry status: TerminatedLast update posted: September 30, 2026Query verification: October 16, 2026
NCT07825753 · Protein-Matched ADC or PDC Umbrella Trial in Advanced Pancreatic and Breast CancerRegistry status: Not yet recruitingLast update posted: September 17, 2026Query verification: October 16, 2026
Source issues and references
References include queries and bibliographic handbook attributions; not all are clinical studies. Human review remains pending.
- ODS-EXERCISE
NIH ODS: Exercise and athletic performance
October 16, 2026
- PC-CITRULLINE
PubChem L-citrulline (CID 9750)
October 16, 2026
- PMID20386132
Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness
October 16, 2026
- PMID30097067
October 16, 2026
- SEARCH-PUBMED-citrulline
PubMed/MED targeted search: TITLE_ABS:citrulline AND TITLE_ABS:exercise AND TITLE_ABS:randomized
October 16, 2026