Neurology, cognition and sleep
Conceptual educational illustration of DSIP / Emideltide in a glass vial, labelled MOLECULE PROFILE.

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MOLECULE PROFILE

DSIP / Emideltide

Peptide or peptide-related

Peptide historically investigated for sleep, with community promotion extending beyond small human studies.

Sources checked · October 16, 2026

Published for review · Scientific, medical, translation and citation review pending. Reported uses are not authorized indications. Frequency reflects mentions in supplied sources, not sales or global clinical prevalence.

Identity and synonyms

Identity follows the supplied name and synonyms; no additional identity description is supplied.

Synonyms: Delta sleep-inducing peptide

Peptide or peptide-related · Peptide or peptide derivative

Detailed molecular class: Neuropeptide candidate

Supplied sequence or chemical reference

See identity note; no supplier sequence accepted as verification.

Mechanism

Proposed sleep modulation; mechanism is not a validated treatment indication.

Evidence and critical reading

Reported scientific and empirical uses

Sleep and circadian rhythms

Handbooks describe sleep onset and deep sleep, alone or with Epitalon. Sleep initiation, sleep architecture, daytime functioning and long-term safety need separate evaluation.

Human evidence

Small double-blind insomnia trial found weak/selective effects, not major therapeutic benefit.

Preclinical evidence

Sleep-related experimental effects cannot establish chronic insomnia treatment.

Critical reading and limitations

The insomnia trial reviewed included 16 participants and selective findings that do not establish a broadly effective therapy. Handbooks propose differing frequencies and cycles; nighttime combinations do not inherit validation from individual studies.

Evidence applies to the exact molecule, formulation, route, population and endpoint studied. Supplier identity, purity and clinical equivalence are unverified.

Source-specific regimens

Descriptive source observations, not individual recommendations.

Regulatory product labeling

Listed regimens preserve source/context. An empty layer means no regimen attributable to this identity was verified in this review; it does not prove universal absence of data.

Human-study exposure

Listed regimens preserve source/context. An empty layer means no regimen attributable to this identity was verified in this review; it does not prove universal absence of data.

Empirical handbook

NOT A RECOMMENDATION.Each amount is attributed to the source identified for that entry: regulatory product labeling, human research, or community and practice sources. These source categories have different evidentiary roles. They are not medical advice, not a protocol, not a recommended or safe dose, and not evidence that it works. Do not use them to start, change or stop any treatment. Talk to a qualified healthcare professional.

Reported by Peptide Handbook — James B. LaValle, Gordon Crozier, Joseph P. Cleaver and Andrew Heyman

100 mcg · Amount per administration

Frequency
Daily per source.
Duration
Not stated on selected page.
Route
Subcutaneous
Context
Described sleep promotion.
Presentation
1 mg/mL; 3-mL vial per source.
Interpretation
Does not validate efficacy or safety of this regimen; attributed to the handbook.

manual01 · Page 45 · October 16, 2026

NOT A RECOMMENDATION.Each amount is attributed to the source identified for that entry: regulatory product labeling, human research, or community and practice sources. These source categories have different evidentiary roles. They are not medical advice, not a protocol, not a recommended or safe dose, and not evidence that it works. Do not use them to start, change or stop any treatment. Talk to a qualified healthcare professional.

Regulation and safety

Jurisdiction-specific regulatory context

Jurisdiction-specific approval not verified in this card; do not infer global nonapproval.

Adverse effects and unknowns

Safety of community exposure and combinations with sedatives has not been established; do not claim a proven interaction where none was characterized.

Contraindications

See supported safety statements and exact product label; a complete contraindication set has not been established for this catalog material.

A complete list must match the exact authorized product. For experimental materials without verified human labeling, a complete contraindication set is not established here. No list does not mean safety.

Interactions

Only explicitly cited interactions may be asserted; unstudied combinations remain unknown, not interaction-free.

Separate documented interaction, pharmacologic plausibility and unknown interaction. Absence of a blend trial does not establish compatibility.

Studies and trials

Selected studies

PMID1299794 · Double-blind matched-pair placebo study

Chronic insomnia.

Intravenous, brief exposure.

Weak selective effects; authors did not expect major therapeutic benefit.

Does not validate handbook SC dosing or an Epitalon stack.

n = 16

Trials attributed in the package

No trials are attributed in this record.

Trial registration does not establish efficacy or validate commercial material.

Query candidates; attribution pending

DSIP · 0 unfiltered query results, not authenticated trials

Query verification: October 16, 2026

Exact phrase intervention query; first three most recently updated records, not exhaustive. Aliases may be missed and heterogeneous products may appear. The total is the unfiltered registry query count, not authenticated trials. Source-integrity holds are excluded from ordinary listings.

View trial registry query

Source issues and references

References include queries and bibliographic handbook attributions; not all are clinical studies. Human review remains pending.

  1. PMID1299794

    Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study.

    Bes F, Hofman W, Schuur J, Van Boxtel C.

    October 16, 2026

  2. R06

    FDA: current bulk-substance safety-risk page

  3. R18

    Bes et al.: DSIP insomnia trial, 1992

  4. manual01

    Peptide Handbook — James B. LaValle, Gordon Crozier, Joseph P. Cleaver and Andrew Heyman

    James B. LaValle; Gordon Crozier; Joseph P. Cleaver; Andrew Heyman

    October 16, 2026

    Bibliographic attribution only. The supplied handbook is a secondary empirical practice source, not clinical verification. Private source files and supplier/download destinations are not provided here.

  5. pdf01

    PEPNEXA 2.pdf

    October 16, 2026

  6. pdf02

    ELLA PEPTIDES.pdf

    October 16, 2026

  7. pdf03

    zlz list 26.8.5.pdf

    October 16, 2026

  8. pdf05

    PEPNEXA.pdf

    October 16, 2026

  9. pdf07

    US Peptide MangerCorp(1).pdf

    October 16, 2026

  10. pdf09

    PeptideFactory.pdf

    October 16, 2026

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