GH/IGF axis
Conceptual educational illustration of Ipamorelin / Ipamorelina in a glass vial, labelled MOLECULE PROFILE.

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MOLECULE PROFILE

Ipamorelin / Ipamorelina

Peptide or peptide-related

GH secretagogue also studied as a ghrelin-receptor agonist for gastrointestinal motility. Investigated use and community use are different contexts.

Sources checked · October 16, 2026

Published for review · Scientific, medical, translation and citation review pending. Reported uses are not authorized indications. Frequency reflects mentions in supplied sources, not sales or global clinical prevalence.

Identity and synonyms

Identity follows the supplied name and synonyms; no additional identity description is supplied.

Synonyms: Ipamorelin acetate

Peptide or peptide-related · Peptide or peptide derivative

Detailed molecular class: Ghrelin-receptor agonist peptide

Supplied sequence or chemical reference

See identity note; no supplier sequence accepted as verification.

Mechanism

Stimulates ghrelin-receptor pathways; selectivity does not mean risk-free GH enhancement.

Evidence and critical reading

Reported scientific and empirical uses

GH/IGF hormonal axis

Handbooks describe body composition, recovery and GHRH combinations. Postoperative-ileus evidence cannot be presented as proof of sports recovery.

Human evidence

Postoperative ileus randomized trial did not meet its key meal-tolerance endpoint; no validation of bodybuilding or recovery stacks.

Preclinical evidence

Receptor pharmacology does not demonstrate long-term functional gains.

Critical reading and limitations

A phase II trial enrolled 117 participants and found no significant difference in its primary solid-food-tolerance endpoint. Administration was intravenous in hospital, unlike community subcutaneous cycles. A lower response of another hormone does not establish general safety.

Evidence applies to the exact molecule, formulation, route, population and endpoint studied. Supplier identity, purity and clinical equivalence are unverified.

Source-specific regimens

Descriptive source observations, not individual recommendations.

Regulatory product labeling

Listed regimens preserve source/context. An empty layer means no regimen attributable to this identity was verified in this review; it does not prove universal absence of data.

Human-study exposure

Listed regimens preserve source/context. An empty layer means no regimen attributable to this identity was verified in this review; it does not prove universal absence of data.

Empirical handbook

NOT A RECOMMENDATION.Each amount is attributed to the source identified for that entry: regulatory product labeling, human research, or community and practice sources. These source categories have different evidentiary roles. They are not medical advice, not a protocol, not a recommended or safe dose, and not evidence that it works. Do not use them to start, change or stop any treatment. Talk to a qualified healthcare professional.

Reported by 2.pdf

100; 300–500 mcg · Amount per administration

Frequency
1–3 times daily; quantities presented by “level”.
Duration
8–12 weeks per source.
Route
Subcutaneous
Context
Tiered handbook regimen, not an escalation recommended by this guide.
Presentation
Not stated on selected page.
Interpretation
Does not validate efficacy or safety of this regimen; attributed to the handbook.

manual07 · Page 18 · October 16, 2026

NOT A RECOMMENDATION.Each amount is attributed to the source identified for that entry: regulatory product labeling, human research, or community and practice sources. These source categories have different evidentiary roles. They are not medical advice, not a protocol, not a recommended or safe dose, and not evidence that it works. Do not use them to start, change or stop any treatment. Talk to a qualified healthcare professional.

Regulation and safety

Jurisdiction-specific regulatory context

Jurisdiction-specific approval not verified in this card; do not infer global nonapproval.

Adverse effects and unknowns

Serious events occurred in a postoperative IV setting; causality is not assumed. Other injectable routes have inadequate safety data.

Contraindications

See supported safety statements and exact product label; a complete contraindication set has not been established for this catalog material.

A complete list must match the exact authorized product. For experimental materials without verified human labeling, a complete contraindication set is not established here. No list does not mean safety.

Interactions

Only explicitly cited interactions may be asserted; unstudied combinations remain unknown, not interaction-free.

Separate documented interaction, pharmacologic plausibility and unknown interaction. Absence of a blend trial does not establish compatibility.

Studies and trials

Selected studies

PMID25331030 · Randomized placebo-controlled phase II

Post-bowel-surgery patients; 114 in safety analysis.

Hospital intravenous administration.

No significant difference in primary solid-food endpoint (p=0.15).

Population and route differ from community SC cycles.

n = 117

Trials attributed in the package

NCT00672074 · Safety and Efficacy of Ipamorelin for Management of Post-Operative IleusRegistry status: CompletedLast update posted: April 14, 2017Query verification: October 16, 2026

NCT01280344 · Safety and Efficacy of Ipamorelin Compared to Placebo for the Recovery of Gastrointestinal FunctionRegistry status: CompletedLast update posted: April 13, 2017Query verification: October 16, 2026

Trial registration does not establish efficacy or validate commercial material.

Query candidates; attribution pending

Ipamorelin · 3 unfiltered query results, not authenticated trials

Query verification: October 16, 2026

Exact phrase intervention query; first three most recently updated records, not exhaustive. Aliases may be missed and heterogeneous products may appear. The total is the unfiltered registry query count, not authenticated trials. Source-integrity holds are excluded from ordinary listings.

View trial registry query

NCT07717866 · Trifecta Research StudyRegistry status: Active, not recruitingLast update posted: July 21, 2026Query verification: October 16, 2026

NCT00672074 · Safety and Efficacy of Ipamorelin for Management of Post-Operative IleusRegistry status: CompletedLast update posted: April 14, 2017Query verification: October 16, 2026

NCT01280344 · Safety and Efficacy of Ipamorelin Compared to Placebo for the Recovery of Gastrointestinal FunctionRegistry status: CompletedLast update posted: April 13, 2017Query verification: October 16, 2026

Source issues and references

References include queries and bibliographic handbook attributions; not all are clinical studies. Human review remains pending.

  1. PMID25331030

    Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients.

    Beck DE, Sweeney WB, McCarter MD, Ipamorelin 201 Study Group.

    October 16, 2026

  2. R06

    FDA: current bulk-substance safety-risk page

  3. R12

    Beck et al.: ipamorelin postoperative ileus trial, 2014

  4. manual07

    2.pdf

    October 16, 2026

  5. pdf01

    PEPNEXA 2.pdf

    October 16, 2026

  6. pdf03

    zlz list 26.8.5.pdf

    October 16, 2026

  7. pdf05

    PEPNEXA.pdf

    October 16, 2026

  8. pdf07

    US Peptide MangerCorp(1).pdf

    October 16, 2026

  9. pdf09

    PeptideFactory.pdf

    October 16, 2026

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