Skin, hair and cosmetics
Conceptual educational illustration of Melanotan II in a glass vial, labelled MOLECULE PROFILE.

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MOLECULE PROFILE

Melanotan II

Peptide or peptide-related

Melanocortin analogue promoted for tanning and sometimes sexual effects. Its profile differs from afamelanotide and bremelanotide.

Sources checked · October 16, 2026

Published for review · Scientific, medical, translation and citation review pending. Reported uses are not authorized indications. Frequency reflects mentions in supplied sources, not sales or global clinical prevalence.

Identity and synonyms

Identity follows the supplied name and synonyms; no additional identity description is supplied.

Synonyms: MT-II · MT2

Peptide or peptide-related · Peptide or peptide derivative

Detailed molecular class: Melanocortin analogue peptide

Supplied sequence or chemical reference

See identity note; no supplier sequence accepted as verification.

Mechanism

Melanocortin activity affecting pigmentation and other physiology.

Evidence and critical reading

Reported scientific and empirical uses

Sexual function · Skin, hair and cosmetics

Handbooks include loading and maintenance schedules. They are documented as reported practice without turning UV exposure or escalation instructions into guide recommendations.

Human evidence

No approved cosmetic tanning indication established. Case reports and product testing concern harms, not proven benefit.

Preclinical evidence

Receptor effects do not establish safe tanning.

Critical reading and limitations

TGA warnings and published cases preclude a safe-tanning claim. Reported nevus changes and serious events require context: a case does not quantify incidence or establish causality on its own. Inconsistent products add exposure uncertainty.

Evidence applies to the exact molecule, formulation, route, population and endpoint studied. Supplier identity, purity and clinical equivalence are unverified.

Source-specific regimens

Descriptive source observations, not individual recommendations.

Regulatory product labeling

Listed regimens preserve source/context. An empty layer means no regimen attributable to this identity was verified in this review; it does not prove universal absence of data.

Human-study exposure

Listed regimens preserve source/context. An empty layer means no regimen attributable to this identity was verified in this review; it does not prove universal absence of data.

Empirical handbook

NOT A RECOMMENDATION.Each amount is attributed to the source identified for that entry: regulatory product labeling, human research, or community and practice sources. These source categories have different evidentiary roles. They are not medical advice, not a protocol, not a recommended or safe dose, and not evidence that it works. Do not use them to start, change or stop any treatment. Talk to a qualified healthcare professional.

Reported by 2.pdf

100–250 mcg · Total daily amount

Frequency
Daily in the comparison table.
Duration
Table mentions 2–4-week loading plus maintenance without a detailed regimen.
Route
Table lists SC or nasal; the dose is not unambiguously paired with a route.
Context
Described tanning use; no UV exposure recommendation.
Presentation
Not stated on selected page.
Interpretation
Not presented as a standard regimen: route and product ambiguity remain.

manual07 · Page 49 · October 16, 2026

NOT A RECOMMENDATION.Each amount is attributed to the source identified for that entry: regulatory product labeling, human research, or community and practice sources. These source categories have different evidentiary roles. They are not medical advice, not a protocol, not a recommended or safe dose, and not evidence that it works. Do not use them to start, change or stop any treatment. Talk to a qualified healthcare professional.

Regulation and safety

Jurisdiction-specific regulatory context

Jurisdiction-specific approval not verified in this card; do not infer global nonapproval.

Adverse effects and unknowns

Reports include priapism and serious systemic events; melanoma reports do not establish an incidence or causal risk estimate.

Contraindications

See supported safety statements and exact product label; a complete contraindication set has not been established for this catalog material.

A complete list must match the exact authorized product. For experimental materials without verified human labeling, a complete contraindication set is not established here. No list does not mean safety.

Interactions

Only explicitly cited interactions may be asserted; unstudied combinations remain unknown, not interaction-free.

Separate documented interaction, pharmacologic plausibility and unknown interaction. Absence of a blend trial does not establish compatibility.

Studies and trials

Selected studies

No selected studies are attributed in this record.

Trials attributed in the package

No trials are attributed in this record.

Trial registration does not establish efficacy or validate commercial material.

Query candidates; attribution pending

Melanotan II · 1 unfiltered query results, not authenticated trials

Query verification: October 16, 2026

Exact phrase intervention query; first three most recently updated records, not exhaustive. Aliases may be missed and heterogeneous products may appear. The total is the unfiltered registry query count, not authenticated trials. Source-integrity holds are excluded from ordinary listings.

View trial registry query

Source issues and references

The official registry record NCT07437560 contains mock, fictional or example-study wording. It is excluded from ordinary trial listings pending source authentication. A registry entry does not establish that a genuine study was conducted or that clinical results exist. · NCT07437560

References include queries and bibliographic handbook attributions; not all are clinical studies. Human review remains pending.

  1. R06

    FDA: current bulk-substance safety-risk page

  2. R33

    TGA: melanotan tanning warning, 2025

  3. R34

    TGA: Melanotan II laboratory testing, August 2026

  4. manual07

    2.pdf

    October 16, 2026

  5. pdf01

    PEPNEXA 2.pdf

    October 16, 2026

  6. pdf02

    ELLA PEPTIDES.pdf

    October 16, 2026

  7. pdf03

    zlz list 26.8.5.pdf

    October 16, 2026

  8. pdf05

    PEPNEXA.pdf

    October 16, 2026

  9. pdf07

    US Peptide MangerCorp(1).pdf

    October 16, 2026

  10. NCT07437560

    ClinicalTrials.gov NCT07437560 — source-integrity review hold

    October 18, 2026

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