Identity and synonyms
Catalog label is recorded; analytical identity and equivalence are not established.
Nonpeptide agent · Amino acid or derivative
Detailed molecular class: Nonpeptide agent; see mechanism for subtype
Supplied sequence or chemical reference
PubChem CID: 145742
Molecular formula: C5H9NO2
IUPAC: (2S)-pyrrolidine-2-carboxylic acid
Source: PC-PROLINE
Database chemical reference; does not certify supplier vial, salt, isomer or formulation.
Mechanism
Structural collagen amino acid and participant in cell metabolism.
Evidence and critical reading
Reported scientific and empirical uses
Replacement and nutritional context · Recovery and connective tissue · Skin, hair and cosmetics
Included in recovery/skin blends; being a collagen component does not prove administration regenerates tissue.
Human evidence
Collagen-supplement or cell-experiment results are not attributable to isolated proline. No injectable clinical repair regimen was verified here.
Preclinical evidence
Do not equate mechanism, cell culture or animal work with a clinical outcome. The specific level is detailed in the evidence assessment.
Critical reading and limitations
Collagen-supplement or cell-experiment results are not attributable to isolated proline. No injectable clinical repair regimen was verified here.
Collagen-supplement or cell-experiment results are not attributable to isolated proline. No injectable clinical repair regimen was verified here.
Source-specific regimens
Descriptive source observations, not individual recommendations.
Regulatory product labeling
No numerical human dose is assigned: reviewed sources did not verify a regimen attributable to this material, route and indication. Other molecules’ doses, animal exposures, vial amounts and dietary requirements are not substituted.
Human-study exposure
No numerical human dose is assigned: reviewed sources did not verify a regimen attributable to this material, route and indication. Other molecules’ doses, animal exposures, vial amounts and dietary requirements are not substituted.
Empirical handbook
No numerical human dose is assigned: reviewed sources did not verify a regimen attributable to this material, route and indication. Other molecules’ doses, animal exposures, vial amounts and dietary requirements are not substituted.
Regulation and safety
Jurisdiction-specific regulatory context
This record does not verify FDA/EMA authorization of the commercial identity. Where a specific medicine/product exists, jurisdiction/indication are detailed in cited sources; they do not transfer to supplier material.
Adverse effects and unknowns
Distinguish nutritional need from pharmacologic intervention; blend interactions/parenteral exposure remain undefined.
Contraindications
A complete list must match the exact authorized product. For experimental materials without verified human labeling, a complete contraindication set is not established here. No list does not mean safety.
Interactions
Separate documented interaction, pharmacologic plausibility and unknown interaction. Absence of a blend trial does not establish compatibility.
Studies and trials
Selected studies
No selected studies are attributed in this record.
Trials attributed in the package
No trials are attributed in this record.
Trial registration does not establish efficacy or validate commercial material.
Query candidates; attribution pending
Proline · 174 unfiltered query results, not authenticated trials
Query verification: October 16, 2026
Exact phrase intervention query; first three most recently updated records, not exhaustive. Aliases may be missed and heterogeneous products may appear. The total is the unfiltered registry query count, not authenticated trials. Source-integrity holds are excluded from ordinary listings.
View trial registry queryNCT07020221 · A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid TumorsRegistry status: RecruitingLast update posted: October 15, 2026Query verification: October 16, 2026
NCT07547878 · Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD)Registry status: Enrolling by invitationLast update posted: October 13, 2026Query verification: October 16, 2026
NCT05400733 · Prandial Metabolic Phenotype in AdultsRegistry status: Active, not recruitingLast update posted: October 5, 2026Query verification: October 16, 2026
Source issues and references
References include queries and bibliographic handbook attributions; not all are clinical studies. Human review remains pending.
- PC-PROLINE
PubChem L-proline (CID 145742)
October 16, 2026
- SEARCH-PUBMED-proline
PubMed/MED targeted search: TITLE_ABS:proline AND TITLE_ABS:supplementation AND TITLE_ABS:human
October 16, 2026
- pdf09
PeptideFactory.pdf
October 16, 2026