Aging and senescence
Conceptual educational illustration of Epitalon / Epitalón in a glass vial, labelled MOLECULE PROFILE.

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MOLECULE PROFILE

Epitalon / Epitalón

Peptide or peptide-related

Tetrapeptide promoted for longevity and sleep. Proposed mechanisms and cell findings must be distinguished from human health outcomes.

Sources checked · October 16, 2026

Published for review · Scientific, medical, translation and citation review pending. Reported uses are not authorized indications. Frequency reflects mentions in supplied sources, not sales or global clinical prevalence.

Identity and synonyms

Identity follows the supplied name and synonyms; no additional identity description is supplied.

Synonyms: Epithalon · AEDG

Peptide or peptide-related · Peptide or peptide derivative

Detailed molecular class: Tetrapeptide

Supplied sequence or chemical reference

See identity note; no supplier sequence accepted as verification.

Mechanism

Telomerase/telomere effects studied in cells.

Evidence and critical reading

Reported scientific and empirical uses

Aging research · Sleep and circadian rhythms

Handbooks describe short repeated cycles for circadian rhythm and anti-aging. Their duration is a source claim rather than a demonstrated aging-prevention schedule.

Human evidence

No validated human lifespan extension follows from these cell experiments. Epithalamin extract studies are not equivalent evidence.

Preclinical evidence

2025 cell study includes cancer-cell ALT findings and a linked correction that must accompany review.

Critical reading and limitations

A 2025 study examined telomere length and maintenance pathways in cell lines, including cancer cells, and has a linked correction. It does not show longer human life or harmless telomere stimulation in every context.

Evidence applies to the exact molecule, formulation, route, population and endpoint studied. Supplier identity, purity and clinical equivalence are unverified.

Source-specific regimens

Descriptive source observations, not individual recommendations.

Regulatory product labeling

Listed regimens preserve source/context. An empty layer means no regimen attributable to this identity was verified in this review; it does not prove universal absence of data.

Human-study exposure

Listed regimens preserve source/context. An empty layer means no regimen attributable to this identity was verified in this review; it does not prove universal absence of data.

Empirical handbook

NOT A RECOMMENDATION.Each amount is attributed to the source identified for that entry: regulatory product labeling, human research, or community and practice sources. These source categories have different evidentiary roles. They are not medical advice, not a protocol, not a recommended or safe dose, and not evidence that it works. Do not use them to start, change or stop any treatment. Talk to a qualified healthcare professional.

Reported by 2.pdf

5–10 mg · Total daily amount

Frequency
Daily
Duration
20 days; source proposes repetition 1–2 times yearly.
Route
Subcutaneous
Context
Sleep/longevity per source.
Presentation
Not stated on selected page.
Interpretation
Does not validate efficacy or safety of this regimen; attributed to the handbook.

manual07 · Page 30 · October 16, 2026

NOT A RECOMMENDATION.Each amount is attributed to the source identified for that entry: regulatory product labeling, human research, or community and practice sources. These source categories have different evidentiary roles. They are not medical advice, not a protocol, not a recommended or safe dose, and not evidence that it works. Do not use them to start, change or stop any treatment. Talk to a qualified healthcare professional.

Regulation and safety

Jurisdiction-specific regulatory context

Jurisdiction-specific approval not verified in this card; do not infer global nonapproval.

Adverse effects and unknowns

Clinical chronic safety unknown; telomere elongation cannot be used as reassurance about cancer risk.

Contraindications

See supported safety statements and exact product label; a complete contraindication set has not been established for this catalog material.

A complete list must match the exact authorized product. For experimental materials without verified human labeling, a complete contraindication set is not established here. No list does not mean safety.

Interactions

Only explicitly cited interactions may be asserted; unstudied combinations remain unknown, not interaction-free.

Separate documented interaction, pharmacologic plausibility and unknown interaction. Absence of a blend trial does not establish compatibility.

Studies and trials

Selected studies

PMID40908429 · Cell experiment

Normal and cancer cell lines.

Cell-culture exposure.

Telomere-length and maintenance-mechanism changes.

Does not show longer human life; linked correction PMID41240216.

PMID22117547 · Cell experiment

HeLa cells/DNA assays.

Fluorescent peptides, in vitro.

Nuclear penetration/DNA interaction.

Labeling/culture are not patient-vial distribution or benefit.

Trials attributed in the package

No trials are attributed in this record.

Trial registration does not establish efficacy or validate commercial material.

Query candidates; attribution pending

Epitalon · 0 unfiltered query results, not authenticated trials

Query verification: October 16, 2026

Exact phrase intervention query; first three most recently updated records, not exhaustive. Aliases may be missed and heterogeneous products may appear. The total is the unfiltered registry query count, not authenticated trials. Source-integrity holds are excluded from ordinary listings.

View trial registry query

Source issues and references

References include queries and bibliographic handbook attributions; not all are clinical studies. Human review remains pending.

  1. PMID22117547

    Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.

    Fedoreyeva LI, Kireev II, Khavinson VKh, Vanyushin BF.

    October 16, 2026

  2. PMID40908429

    Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.

    Al-Dulaimi S, Thomas R, Matta S, Roberts T.

    October 16, 2026

  3. PMID41240216

    Correction: Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.

    Al-Dulaimi S, Thomas R, Matta S, Roberts T.

    October 16, 2026

  4. R06

    FDA: current bulk-substance safety-risk page

  5. R24

    Al-Dulaimi et al.: Epitalon in cell lines, 2025

  6. manual07

    2.pdf

    October 16, 2026

  7. pdf01

    PEPNEXA 2.pdf

    October 16, 2026

  8. pdf02

    ELLA PEPTIDES.pdf

    October 16, 2026

  9. pdf03

    zlz list 26.8.5.pdf

    October 16, 2026

  10. pdf05

    PEPNEXA.pdf

    October 16, 2026

  11. pdf07

    US Peptide MangerCorp(1).pdf

    October 16, 2026

  12. pdf09

    PeptideFactory.pdf

    October 16, 2026

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