Identity and synonyms
Kisspeptin-54 is not interchangeable with kisspeptin-10; primary trial uses ISRCTN17271094.
Synonyms: Metastin
Peptide or peptide-related · Peptide or peptide derivative
Detailed molecular class: Reproductive neuropeptide
Supplied sequence or chemical reference
See identity note; no supplier sequence accepted as verification.
Mechanism
KISS1R/GnRH-related reproductive signaling.
Evidence and critical reading
Reported scientific and empirical uses
Fertility and reproduction · Sexual function
Investigated for reproductive signaling/sexual response; not interchangeable with kisspeptin-10.
Human evidence
Crossover trial in men with HSDD studied brain processing and arousal, not durable everyday efficacy.
Preclinical evidence
Reproductive biology does not validate all fertility or libido claims.
Critical reading and limitations
The selected male HSDD trial was small/brief; it does not establish sustained fertility or a community SC regimen.
Evidence applies to the exact molecule, formulation, route, population and endpoint studied. Supplier identity, purity and clinical equivalence are unverified.
Source-specific regimens
Descriptive source observations, not individual recommendations.
Regulatory product labeling
No numerical human dose is assigned: reviewed sources did not verify a regimen attributable to this material, route and indication. Other molecules’ doses, animal exposures, vial amounts and dietary requirements are not substituted.
Human-study exposure
No numerical human dose is assigned: reviewed sources did not verify a regimen attributable to this material, route and indication. Other molecules’ doses, animal exposures, vial amounts and dietary requirements are not substituted.
Empirical handbook
No numerical human dose is assigned: reviewed sources did not verify a regimen attributable to this material, route and indication. Other molecules’ doses, animal exposures, vial amounts and dietary requirements are not substituted.
Regulation and safety
Jurisdiction-specific regulatory context
Jurisdiction-specific approval not verified in this card; do not infer global nonapproval.
Adverse effects and unknowns
Brief controlled exposure cannot establish long-term safety or hormonal-drug combinations.
Gonadal biomarkers and sexual effects do not replace long-term reproductive-safety assessment.
Contraindications
See supported safety statements and exact product label; a complete contraindication set has not been established for this catalog material.
A complete list must match the exact authorized product. For experimental materials without verified human labeling, a complete contraindication set is not established here. No list does not mean safety.
Interactions
Only explicitly cited interactions may be asserted; unstudied combinations remain unknown, not interaction-free.
Separate documented interaction, pharmacologic plausibility and unknown interaction. Absence of a blend trial does not establish compatibility.
Studies and trials
Selected studies
PMID36735255 · Randomized controlled trial
Men with hypoactive sexual desire; 32 completed.
IV infusion, acute crossover.
Changes in brain processing/arousal variables.
Acute markers are not chronic efficacy; do not extrapolate to SC kisspeptin-10.
n = 37
Trials attributed in the package
No trials are attributed in this record.
Trial registration does not establish efficacy or validate commercial material.
Query candidates; attribution pending
Kisspeptin-54 · 19 unfiltered query results, not authenticated trials
Query verification: October 16, 2026
Exact phrase intervention query; first three most recently updated records, not exhaustive. Aliases may be missed and heterogeneous products may appear. The total is the unfiltered registry query count, not authenticated trials. Source-integrity holds are excluded from ordinary listings.
View trial registry queryNCT04648969 · Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic HypogonadismRegistry status: CompletedLast update posted: August 26, 2026Query verification: October 16, 2026
NCT07224438 · Kisspeptin Administration Subcutaneously to Patients With Hypothalamic AmenorrheaRegistry status: RecruitingLast update posted: July 13, 2026Query verification: October 16, 2026
NCT05896293 · Kisspeptin Administration Subcutaneously to Patients With IHHRegistry status: RecruitingLast update posted: July 13, 2026Query verification: October 16, 2026
Source issues and references
The Kisspeptin chapter presents a long sequence; do not automatically assign its regimen to the marketed kisspeptin-10 decapeptide. · manual01 · Page 64
References include queries and bibliographic handbook attributions; not all are clinical studies. Human review remains pending.
- PMID36735255
Mills EG, Ertl N, Wall MB, Thurston L, Yang L, Suladze S, Hunjan T, Phylactou M, Patel B, Muzi B, Ettehad D, Bassett PA, Howard J, Rabiner EA, Bech P, Abbara A, Goldmeier D, Comninos AN, Dhillo WS.
October 16, 2026
- manual01
Peptide Handbook — James B. LaValle, Gordon Crozier, Joseph P. Cleaver and Andrew Heyman
James B. LaValle; Gordon Crozier; Joseph P. Cleaver; Andrew Heyman
October 16, 2026
Bibliographic attribution only. The supplied handbook is a secondary empirical practice source, not clinical verification. Private source files and supplier/download destinations are not provided here.