Identity and synonyms
Catalog label is recorded; analytical identity and equivalence are not established.
Peptide or peptide-related · Peptide or peptide derivative
Detailed molecular class: Peptide or peptide-derivative label; see identity
Supplied sequence or chemical reference
Commercial identity or variant awaiting clarification.
Mechanism
The name commonly refers to palmitoyl pentapeptide-4/pal-KTTKS in a cosmetic formulation; confirm exact INCI.
Evidence and critical reading
Reported scientific and empirical uses
Skin, hair and cosmetics
Topical cosmetic use for photoaging; distinguish active ingredient, commercial raw material and finished cream.
Human evidence
A 12-week, 93-woman facial comparison trial found improvement with a pal-KTTKS-containing moisturizer. It did not evaluate injection or Matrixyl 3000.
Preclinical evidence
Do not equate mechanism, cell culture or animal work with a clinical outcome. The specific level is detailed in the evidence assessment.
Critical reading and limitations
A 12-week, 93-woman facial comparison trial found improvement with a pal-KTTKS-containing moisturizer. It did not evaluate injection or Matrixyl 3000.
A 12-week, 93-woman facial comparison trial found improvement with a pal-KTTKS-containing moisturizer. It did not evaluate injection or Matrixyl 3000.
Source-specific regimens
Descriptive source observations, not individual recommendations.
Regulatory product labeling
Listed regimens preserve source/context. An empty layer means no regimen attributable to this identity was verified in this review; it does not prove universal absence of data.
Human-study exposure
NOT A RECOMMENDATION.Each amount is attributed to the source identified for that entry: regulatory product labeling, human research, or community and practice sources. These source categories have different evidentiary roles. They are not medical advice, not a protocol, not a recommended or safe dose, and not evidence that it works. Do not use them to start, change or stop any treatment. Talk to a qualified healthcare professional.
Reported by Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin.
3 ppm · Product concentration; not administered mass
- Frequency
- Topical product per trial
- Duration
- 12 weeks
- Route
- Topical
- Context
- 93 women; research-product concentration, not an injectable dose.
- Presentation
- Pal-KTTKS moisturizer; not concentration of Matrixyl raw material.
- Interpretation
- Research exposure: not a prescription or starting regimen. It does not reconstruct protocol titration, exclusions or monitoring.
PMID18492182 · October 16, 2026
NOT A RECOMMENDATION.Each amount is attributed to the source identified for that entry: regulatory product labeling, human research, or community and practice sources. These source categories have different evidentiary roles. They are not medical advice, not a protocol, not a recommended or safe dose, and not evidence that it works. Do not use them to start, change or stop any treatment. Talk to a qualified healthcare professional.
Empirical handbook
Listed regimens preserve source/context. An empty layer means no regimen attributable to this identity was verified in this review; it does not prove universal absence of data.
Regulation and safety
Jurisdiction-specific regulatory context
This record does not verify FDA/EMA authorization of the commercial identity. Where a specific medicine/product exists, jurisdiction/indication are detailed in cited sources; they do not transfer to supplier material.
Adverse effects and unknowns
Cream tolerability cannot be extrapolated to parenteral delivery. Excipients and other actives may determine irritation/sensitization.
Contraindications
A complete list must match the exact authorized product. For experimental materials without verified human labeling, a complete contraindication set is not established here. No list does not mean safety.
Interactions
Separate documented interaction, pharmacologic plausibility and unknown interaction. Absence of a blend trial does not establish compatibility.
Studies and trials
Selected studies
PMID18492182 · Randomized controlled trial
Women with facial photoaging.
Topical moisturizer, 12-week facial comparison.
Cosmetic-variable improvement with pal-KTTKS.
Not Matrixyl 3000 or injectable material; specific formulation.
n = 93
Trials attributed in the package
No trials are attributed in this record.
Trial registration does not establish efficacy or validate commercial material.
Query candidates; attribution pending
Matrixyl · 0 unfiltered query results, not authenticated trials
Query verification: October 16, 2026
Exact phrase intervention query; first three most recently updated records, not exhaustive. Aliases may be missed and heterogeneous products may appear. The total is the unfiltered registry query count, not authenticated trials. Source-integrity holds are excluded from ordinary listings.
View trial registry querySource issues and references
References include queries and bibliographic handbook attributions; not all are clinical studies. Human review remains pending.
- PMID18492182
Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin.
Robinson LR, Fitzgerald NC, Doughty DG, Dawes NC, Berge CA, Bissett DL.
October 16, 2026
- SEARCH-PUBMED-matrixyl
October 16, 2026
- pdf01
PEPNEXA 2.pdf
October 16, 2026
- pdf05
PEPNEXA.pdf
October 16, 2026
- pdf07
US Peptide MangerCorp(1).pdf
October 16, 2026