Muscle and performance
Conceptual educational illustration of MGF in a glass specimen jar, labelled MOLECULE PROFILE.

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IDENTITY PROFILE

MGF

Peptide or peptide-related

“Mechano growth factor” may mean an IGF-1 transcript, its E region or a synthetic peptide; these are not equivalent identities.

Sources checked · October 16, 2026

Published for review · Scientific, medical, translation and citation review pending. Reported uses are not authorized indications. Frequency reflects mentions in supplied sources, not sales or global clinical prevalence.

Identity and synonyms

Catalog label is recorded; analytical identity and equivalence are not established.

Peptide or peptide-related · Peptide or peptide derivative

Detailed molecular class: Peptide or peptide-derivative label; see identity

Supplied sequence or chemical reference

Commercial identity or variant awaiting clarification.

Mechanism

“Mechano growth factor” may mean an IGF-1 transcript, its E region or a synthetic peptide; these are not equivalent identities.

Evidence and critical reading

Reported scientific and empirical uses

Reported muscle and performance · Recovery and connective tissue

Promoted for muscle/tendon repair; retain separately from PEG-MGF and IGF-1 LR3.

Human evidence

The selected work studied mechanically injured human ligament cells and a rabbit injury model. Human cells do not mean treated human patients.

Preclinical evidence

Do not equate mechanism, cell culture or animal work with a clinical outcome. The specific level is detailed in the evidence assessment.

Critical reading and limitations

The selected work studied mechanically injured human ligament cells and a rabbit injury model. Human cells do not mean treated human patients.

The selected work studied mechanically injured human ligament cells and a rabbit injury model. Human cells do not mean treated human patients.

Source-specific regimens

Descriptive source observations, not individual recommendations.

Regulatory product labeling

No numerical human dose is assigned: reviewed sources did not verify a regimen attributable to this material, route and indication. Other molecules’ doses, animal exposures, vial amounts and dietary requirements are not substituted.

Human-study exposure

No numerical human dose is assigned: reviewed sources did not verify a regimen attributable to this material, route and indication. Other molecules’ doses, animal exposures, vial amounts and dietary requirements are not substituted.

Empirical handbook

No numerical human dose is assigned: reviewed sources did not verify a regimen attributable to this material, route and indication. Other molecules’ doses, animal exposures, vial amounts and dietary requirements are not substituted.

Regulation and safety

Jurisdiction-specific regulatory context

This record does not verify FDA/EMA authorization of the commercial identity. Where a specific medicine/product exists, jurisdiction/indication are detailed in cited sources; they do not transfer to supplier material.

Adverse effects and unknowns

No clinical regimen or commercial-modification safety was established; GH/IGF-1 combination safety is also not demonstrated.

Contraindications

A complete list must match the exact authorized product. For experimental materials without verified human labeling, a complete contraindication set is not established here. No list does not mean safety.

Interactions

Separate documented interaction, pharmacologic plausibility and unknown interaction. Absence of a blend trial does not establish compatibility.

Studies and trials

Selected studies

PMID35457148 · Cells and animal model

Human ACL cells/injured rabbits.

In vitro/animal model.

Cell mobility/experimental ligament repair.

No treated patients or commercial PEG-MGF validation.

Trials attributed in the package

No trials are attributed in this record.

Trial registration does not establish efficacy or validate commercial material.

Query candidates; attribution pending

MGF · 102 unfiltered query results, not authenticated trials

Query verification: October 16, 2026

Exact phrase intervention query; first three most recently updated records, not exhaustive. Aliases may be missed and heterogeneous products may appear. The total is the unfiltered registry query count, not authenticated trials. Source-integrity holds are excluded from ordinary listings.

View trial registry query

NCT03851614 · Study of DNA Damage, Angiogenesis, and PD-L1 Inhibitors in Advanced Solid TumorsRegistry status: Active, not recruitingLast update posted: October 5, 2026Query verification: October 16, 2026

NCT07037420 · ALXN2420 Versus Placebo in Combination With Somatostatin Analogs in Participants With AcromegalyRegistry status: TerminatedLast update posted: August 7, 2026Query verification: October 16, 2026

NCT03253263 · A Clinical Efficacy and Safety Study of OHB-607 in Preventing Bronchopulmonary Dysplasia in Extremely Premature InfantsRegistry status: Active, not recruitingLast update posted: August 3, 2026Query verification: October 16, 2026

Source issues and references

600 mcg/day for five days would imply 3 mg/week versus the written 2-mg limit; PEG-MGF handbooks also conflict. · manual01 · Page 98

References include queries and bibliographic handbook attributions; not all are clinical studies. Human review remains pending.

  1. PMID35457148

    Mechano Growth Factor Accelerates ACL Repair and Improves Cell Mobility of Mechanically Injured Human ACL Fibroblasts by Targeting Rac1-PAK1/2 and RhoA-ROCK1 Pathways.

    Sha Y, Zhang B, Chen L, Hong H, Chi Q.

    October 16, 2026

  2. SEARCH-PUBMED-mgf

    PubMed/MED targeted search: TITLE_ABS:"mechano growth factor" AND TITLE_ABS:human

    October 16, 2026

  3. manual01

    Peptide Handbook — James B. LaValle, Gordon Crozier, Joseph P. Cleaver and Andrew Heyman

    James B. LaValle; Gordon Crozier; Joseph P. Cleaver; Andrew Heyman

    October 16, 2026

    Bibliographic attribution only. The supplied handbook is a secondary empirical practice source, not clinical verification. Private source files and supplier/download destinations are not provided here.

  4. pdf01

    PEPNEXA 2.pdf

    October 16, 2026

  5. pdf02

    ELLA PEPTIDES.pdf

    October 16, 2026

  6. pdf03

    zlz list 26.8.5.pdf

    October 16, 2026

  7. pdf05

    PEPNEXA.pdf

    October 16, 2026

  8. pdf09

    PeptideFactory.pdf

    October 16, 2026

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