Molecule profile · Module 4
Ipamorelin — evidence and research limits
This label describes the research context of this profile, not a product-by-product approval determination. It does not mean every use of the molecule lacks approval. Read the existing evidence details and regulatory context for the specific preparation, indication and jurisdiction; no new approval is inferred.
MOLECULE PROFILE
- Evidence summary
- Investigational — profile context
- The phase II trial evaluated intravenous ipamorelin for postoperative ileus and found no statistically significant efficacy differences on its primary or secondary endpoints. It did not test body recomposition, sleep, longevity, or CJC combinations. A hormonal response is not the same outcome as a clinically meaningful functional benefit. The interpretation is specific to the studied molecule, formulation, route, population, and endpoint. Reported commercial regimens are not validated by a study of a different product or outcome.
- Regulatory status varies by jurisdiction
- The academic source does not establish a current authorization for every preparation sold under this name. Product identity, formulation, indication, jurisdiction, and current official labeling must be checked separately. A discussion of compounding or an advisory meeting is not a product approval.
Educational information for healthcare professionals and the general public. Not individual medical advice, diagnosis, treatment, or a recommendation to use a compound.
Identity and mechanism
Ipamorelin is investigated as an agonist of the ghrelin receptor, a target involved in growth hormone release and gastrointestinal physiology. The cited postoperative-ileus study addresses a specific surgical setting. A receptor mechanism or a measured hormone response does not establish improved strength, sleep, body composition, or the performance of a combination product.
What the evidence supports
The phase II trial evaluated intravenous ipamorelin for postoperative ileus and found no statistically significant efficacy differences on its primary or secondary endpoints. It did not test body recomposition, sleep, longevity, or CJC combinations. A hormonal response is not the same outcome as a clinically meaningful functional benefit.
The interpretation is specific to the studied molecule, formulation, route, population, and endpoint. Reported commercial regimens are not validated by a study of a different product or outcome.
Regulatory context
The academic source does not establish a current authorization for every preparation sold under this name. Product identity, formulation, indication, jurisdiction, and current official labeling must be checked separately. A discussion of compounding or an advisory meeting is not a product approval.
Safety and uncertainty
The postoperative trial does not characterize all community exposures. Human safety cannot be inferred from a cell result, a product name, or lack of events in a small report. These educational adaptations do not provide an administration protocol.
Sport and anti-doping status
The WADA 2026 Prohibited List names ipamorelin among growth hormone secretagogues in section S2.2.4, prohibited at all times (in and out of competition). This is an anti-doping classification, separate from clinical evidence, product quality and regulatory approval. Medical supervision, a prescription or an approved indication does not by itself permit use in sport; any exemption for a documented medical condition is a separate decision by the competent anti-doping organization. The List is revised each year, so check the List in force on the relevant date.
Continue learning
Explore Module 4 in PEPTIDE Academy for the full evidence discussion.
References
Bibliographic sources shown for transparency. Citation verification pending; no citation is marked verified.
- Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402(6762):656-60. DOI: 10.1038/45230. PMID: 10604470.DOI 10.1038/45230 · PMID 10604470
- Beck DE, Sweeney WB, McCarter MD, et al. Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. Int J Colorectal Dis. 2014;29(12):1527-34. DOI: 10.1007/s00384-014-2030-8. PMID: 25331030.DOI 10.1007/s00384-014-2030-8 · PMID 25331030
- World Anti-Doping Agency. International Standard: Prohibited List 2026 (in effect from 1 January 2026). Checked 19 October 2026.
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