Conceptual cutaway mitochondrion with a blue surface and gold internal folds; not a micrograph or treatment-effect image.
AI-generated conceptual editorial illustration; not a verified molecular structure.

What a study's model demonstrates

The human measurements and administration experiments should be read separately.

Two different questions in a 2021 MOTS-c publication.

The human measurements and administration experiments should be read separately.

What was measured

Reynolds and colleagues measured endogenous MOTS-c in muscle and circulation in ten young men who exercised. That component did not administer the peptide. The article also included administration experiments in mice. It is not a trial demonstrating the efficacy of administering it to people.

Transparency

The publication discloses Pinchas Cohen and Changhan Lee as CohBar consultants and shareholders. That disclosure belongs in the reading context; it neither confirms nor invalidates the findings by itself.

Professional context / Contexto profesional

Do not translate animal doses or routes into human regimens. Distinguish endogenous change, intervention and population before summarizing an effect.

Evidence / Evidencia

Study with human measurement components and preclinical experiments.

Limitations / Limitaciones

Limited to this publication; not an exhaustive review of clinical development or analogues.

References

  1. Reynolds JC, Lai RW, Woodhead JST, et al.. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications. 2021
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