Reading guide

What each evidence label means

Classify the claim, not the popularity of the molecule.

Editorial draft; scientific and translation review pending.

Observation, hypothesis and preclinical work

Observation describes what a source or person reports. Hypothesis describes a proposed explanation. Preclinical evidence comes from laboratory or animal models. A cell originating from a human donor is still a cellular experiment. None of these categories is worthless; each answers a different question. The label must remain attached to the specific claim and outcome.

Clinical evidence includes negative results

Early human pharmacology, uncontrolled reports and controlled trials provide different information. The word clinical does not mean positive or definitive. Keep the main endpoint, population, route, follow-up and uncertainty visible. A favorable exploratory subgroup cannot silently replace a negative overall result.

Approval is a separate field

Approval applies to a particular product, indication, population and jurisdiction. A narrow approved use does not validate a different research preparation or a longevity claim. Compounding eligibility, sporting rules and clinical effectiveness also remain separate. These editorial labels are not a formal GRADE assessment or a safety score.